abstract：OBJECTIVES:The aim of this study was to identify meteorological factors that could be associated with an increased risk of community-acquired Legionnaires' disease (LD) in two Swiss regions. DESIGN:Retrospective epidemiological study using discriminant analysis and multivariable Poisson regression. SETTING:We analyse...

journal_title：BMJ open

authors： Conza L,Casati S,Limoni C,Gaia V

更新日期：2013-03-05 00:00:00

abstract：OBJECTIVES:Worldwide, the Irish diaspora experience elevated mortality and morbidity across generations, not accounted for through socioeconomic position. The main objective of the present study was to assess if childhood disadvantage accounts for poorer mental and physical health in adulthood, in second-generation Iri...

journal_title：BMJ open

authors： Das-Munshi J,Clark C,Dewey ME,Leavey G,Stansfeld SA,Prince MJ

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between poststroke fatigue and depression and subsequent mortality in young ischaemic stroke patients in a population-based study. DESIGN:A prospective cohort study. SETTING:All surviving young ischaemic stroke patients living in Hordaland County. PARTICIPANTS:Young ischaem...

journal_title：BMJ open

authors： Naess H,Nyland H

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:In this study, we aimed to determine the performance characteristics of toluidine red unheated serum test on cerebrospinal fluids (CSF-TRUST) as compared to venereal disease research laboratory test on cerebrospinal fluids (CSF-VDRL) for laboratory the diagnosis of neurosyphilis. DESIGN:A cross-sectional stu...

journal_title：BMJ open

authors： Gu W,Yang Y,Wu L,Yang S,Ng LK

更新日期：2013-02-21 00:00:00

abstract：OBJECTIVES:To describe adverse drug events (ADEs) in children under intensive care, identify risk factors and tools that can detect ADEs early, and the impact on length of stay (LOS). DESIGN:A prospective observational study. SETTING:Paediatric intensive care unit of a tertiary care teaching hospital. PATIENTS:239 p...

journal_title：BMJ open

authors： Silva DC,Araujo OR,Arduini RG,Alonso CF,Shibata AR,Troster EJ

更新日期：2013-02-19 00:00:00

abstract：OBJECTIVE:To obtain the views of bereaved parents about their interactions with healthcare staff when their baby died just before or during labour. DESIGN:Qualitative in-depth interview study, following an earlier national survey. All interviews took place during 2011, either face-to-face or on the telephone. Data ana...

journal_title：BMJ open

authors： Downe S,Schmidt E,Kingdon C,Heazell AE

更新日期：2013-02-14 00:00:00

abstract：OBJECTIVE:To examine the associations between consumption of sweetened products, daytime sleepiness (DS) and psychological distress (PD) in a Catholic Middle-Eastern Canadian community, and to test the hypothesis that the association between DS and consumption of sweetened products is mediated by PD. DESIGN:A cross-se...

journal_title：BMJ open

authors： Moubarac JC,Cargo M,Receveur O,Daniel M

更新日期：2013-02-13 00:00:00

abstract：OBJECTIVES:In the UK there are approximately 850 000 new fractures seen each year. Rates of non-union of 5-10% of fractures have been suggested, the cost to the National Health Service of treating non-union has been reported to range between £7000 and £79 000 per person yet there are little actual data available. The o...

journal_title：BMJ open

authors： Mills LA,Simpson AH

更新日期：2013-02-08 00:00:00

abstract：OBJECTIVES:Internalised homonegativity (IH) is hypothesised to be associated with HIV risk behaviour and HIV testing in men who have sex with men (MSM). We sought to determine the social and individual variables associated with IH and the associations between IH and HIV-related behaviours. DESIGN AND SETTING:We examin...

journal_title：BMJ open

authors： Ross MW,Berg RC,Schmidt AJ,Hospers HJ,Breveglieri M,Furegato M,Weatherburn P,European MSM Internet Survey (EMIS) Network.

更新日期：2013-02-04 00:00:00

abstract：OBJECTIVES:Social interaction may be particularly important for people with chronic health conditions, due to the numerous benefits to an individual's health. This paper aims to determine if labour force participation is a factor that influences individuals with chronic health conditions partaking in social or cultural...

journal_title：BMJ open

authors： Callander E,Schofield DJ

更新日期：2013-01-30 00:00:00

abstract：INTRODUCTION:Cyclooxygenase 2 (COX-2) inhibitors have less upper gastrointestinal toxicity than traditional non-steroidal anti-inflammatory drugs (NSAIDs). However, both COX-2 inhibitors and traditional NSAIDs may be associated with adverse cardiovascular side effects. Data from randomised and observational studies sug...

journal_title：BMJ open

authors： Macdonald TM,Mackenzie IS,Wei L,Hawkey CJ,Ford I,SCOT study group collaborators.

更新日期：2013-01-29 00:00:00

abstract：OBJECTIVES:To describe the demographic characteristics and incidence of unintentional fall-related fractures among older adults treated in the US hospital emergency departments (EDs). DESIGN:Retrospective observational study. SETTINGS:Hospitals' ED participants in the National Electronic Injury Surveillance System Al...

journal_title：BMJ open

authors： Orces CH

更新日期：2013-01-24 00:00:00

abstract：OBJECTIVES:To explore the beliefs and expectations of patients and their caregivers about home haemodialysis in Italy where the prevalence of home haemodialysis is low. DESIGN:Semistructured, qualitative interview study with purposive sampling and thematic analysis. SETTING:Four dialysis centres in Italy without home...

journal_title：BMJ open

authors： Tong A,Palmer S,Manns B,Craig JC,Ruospo M,Gargano L,Johnson DW,Hegbrant J,Olsson M,Fishbane S,Strippoli GF

更新日期：2013-01-24 00:00:00

abstract：OBJECTIVES:Patients are often accompanied by family or companions during consultations, but little is known about how this might influence the process. We explored how the presence of a companion in a consultation contributes to communication and the decision-making process. DESIGN:Observational study. SETTING:A teac...

journal_title：BMJ open

authors： Korfage IJ,Audrey S,Hak T,Blazeby JM,Abel J,Campbell R

更新日期：2013-01-16 00:00:00

abstract：OBJECTIVES:To determine whether humour therapy reduces depression (primary outcome), agitation and behavioural disturbances and improves social engagement and quality-of-life in nursing home residents. DESIGN:The Sydney Multisite Intervention of LaughterBosses and ElderClowns study was a single-blind cluster randomise...

journal_title：BMJ open

authors： Low LF,Brodaty H,Goodenough B,Spitzer P,Bell JP,Fleming R,Casey AN,Liu Z,Chenoweth L

更新日期：2013-01-11 00:00:00

abstract：BACKGROUND:To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. OBJECTIVE:To determine delirium prevalence across an acute care facility. DESIGN:A point prevalence study. SETTING:A large tertiary care, teaching hos...

journal_title：BMJ open

authors： Ryan DJ,O'Regan NA,Caoimh RÓ,Clare J,O'Connor M,Leonard M,McFarland J,Tighe S,O'Sullivan K,Trzepacz PT,Meagher D,Timmons S

更新日期：2013-01-07 00:00:00

abstract：OBJECTIVE:We examined the association of different chronic physical and mental conditions, individually or comorbidly on health-related quality of life (QoL) in Chinese children aged ≤14 years in Hong Kong. DESIGN:Population-based cross-sectional survey. PARTICIPANTS:Approximately 7500 Chinese children aged <14 years...

journal_title：BMJ open

authors： Lee SL,Cheung YF,Wong HS,Leung TH,Lam TH,Lau YL

更新日期：2013-01-03 00:00:00

abstract：OBJECTIVES:Low serum amylase (LSA) was reported to be associated with obesity, metabolic syndrome (MetS) and diabetes. However, it is unknown as to whether LSA is associated with non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of MetS and insulin resistance. Therefore, we performed a clinical epidemi...

journal_title：BMJ open

authors： Nakajima K,Oshida H,Muneyuki T,Saito M,Hori Y,Fuchigami H,Kakei M,Munakata H

更新日期：2013-01-03 00:00:00

abstract：OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...

journal_title：BMJ open

authors： Lago P,Bizzarri G,Scalzotto F,Parpaiola A,Amigoni A,Putoto G,Perilongo G

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVE:This paper aims to analyse the variation in the delivery of diagnostic imaging services in order to suggest possible solutions for the reduction of waiting times, increase the quality of services and reduce financial costs. DESIGN:This study provides a logic model to manage waiting times in a regional contex...

journal_title：BMJ open

authors： Nuti S,Vainieri M

更新日期：2012-12-14 00:00:00

abstract：OBJECTIVES:We aimed to examine longitudinally whether workplace bullying was associated with subsequent psychotropic medication among women and men. DESIGN:A cohort study. SETTING:Helsinki, Finland. PARTICIPANTS:Employees of the City of Helsinki, Finland (n=6606, 80% women), 40-60 years at baseline in 2000-2002, and...

journal_title：BMJ open

authors： Lallukka T,Haukka J,Partonen T,Rahkonen O,Lahelma E

更新日期：2012-12-12 00:00:00

abstract：OBJECTIVE:Sinemet, a combination drug containing carbidopa and levodopa is considered the gold standard therapy for the treatment of Parkinson's disease (PD). When approved by the Food and Drug Administration (FDA) in 1988, a maximum daily dosage limit of 800 mg (eight tablets) of the 25/100 carbidopa/levodopa formulat...

journal_title：BMJ open

authors： Brodell DW,Stanford NT,Jacobson CE,Schmidt P,Okun MS

更新日期：2012-12-11 00:00:00

abstract：OBJECTIVES:Compared with controls, multiple sclerosis (MS) patients die, on average, 7-14 years prematurely. Previously, we reported that, 21 years after their participation in the pivotal randomised, controlled trial (RCT) of interferon β-1b, mortality was reduced by 46-47% in the two groups who received active therap...

journal_title：BMJ open

authors： Goodin DS,Ebers GC,Cutter G,Cook SD,O'Donnell T,Reder AT,Kremenchutzky M,Oger J,Rametta M,Beckmann K,Knappertz V

更新日期：2012-11-30 00:00:00

abstract：OBJECTIVES:Respiratory symptoms are associated with spirometry results but more strongly with smoking history, suggesting that alterations in the lung other than those revealed by spirometry contribute to cause symptoms. Smoking may cause obstruction of peripheral airways that is poorly detected by spirometry. The slop...

journal_title：BMJ open

authors： Olofson JY,Houltz B,Nilsson Tengelin M,Bake B

更新日期：2012-11-27 00:00:00

abstract：OBJECTIVES:There currently exists no reliable or validated tool for the assessment of exercise-related injuries in older adults. The purpose was to develop and evaluate the psychometric properties of a questionnaire to measure exercise-related injury in older adults participating in supervised exercise programmes. DES...

journal_title：BMJ open

authors： Stathokostas L,Theou O,Vandervoort T,Raina P

更新日期：2012-11-22 00:00:00

abstract：OBJECTIVES:The aim of the study was to assess whether gastrostomy placement before 18 months of age results in a greater increase in z-score for weight and to assess whether admission rates were reduced postgastrostomy in this age group. DESIGN:Retrospective cross-sectional study. SETTING:Single-centre secondary care...

journal_title：BMJ open

authors： Sharma R,Williams AN,Zaw W

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a condition characterised by severe and persistent fatigue, neurological disturbances, autonomic and endocrine dysfunctions and sleep difficulties that have a pronounced and significant impact on individuals' lives. Current National Institute for...

journal_title：BMJ open

authors： Arroll MA,Howard A

更新日期：2012-11-19 00:00:00

abstract：OBJECTIVES:To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older individuals with chronic obstructive pulmonary disease (COPD), in comparison with their counterparts without COPD. DESIGN:Cross-sectional study. PARTICIPANTS:A population-based sa...

journal_title：BMJ open

authors： Lu Y,Nyunt MS,Gwee X,Feng L,Feng L,Kua EH,Kumar R,Ng TP

更新日期：2012-11-19 00:00:00

abstract：BACKGROUND:Large gaps exist in the implementation of guideline recommendations for cardiovascular disease (CVD) risk management. Electronic decision support (EDS) systems are promising interventions to close these gaps but few have undergone clinical trial evaluation in Australia. We have developed HealthTracker, a mul...

journal_title：BMJ open

authors： Peiris D,Usherwood T,Panaretto K,Harris M,Hunt J,Patel B,Zwar N,Redfern J,Macmahon S,Colagiuri S,Hayman N,Patel A

更新日期：2012-11-19 00:00:00

abstract：OBJECTIVES:To explore the extent to which doctor-rating websites are known and used among a sample of respondents from London. To understand the main predictors of what makes people willing to use doctor-rating websites. DESIGN:A cross-sectional study. SETTING:The Borough of Hammersmith and Fulham, London, England. ...

journal_title：BMJ open

authors： Galizzi MM,Miraldo M,Stavropoulou C,Desai M,Jayatunga W,Joshi M,Parikh S

更新日期：2012-11-12 00:00:00

abstract：OBJECTIVES:To support sustainability of the welfare society enhanced work retention is needed among those with impaired work ability. Partial health-related benefits have been introduced for this target. The aim was to estimate the effects of partial sick leave on transition to disability pension applying propensity sc...

journal_title：BMJ open

authors： Kausto J,Solovieva S,Virta LJ,Viikari-Juntura E

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Implementing venous thromboembolism (VTE) risk assessment guidance on admission to hospital has proved difficult worldwide. In 2010, VTE risk assessment in English hospitals was linked to financial sanctions. This study investigated possible barriers and facilitators for VTE risk assessment in medical patien...

journal_title：BMJ open

authors： Basey AJ,Krska J,Kennedy TD,Mackridge AJ

更新日期：2012-11-06 00:00:00

abstract：OBJECTIVES:To investigate whether bicycling to school improves cardiometabolic risk factor profile and cardiorespiratory fitness among children. DESIGN:Prospective, blinded, randomised controlled trial. SETTING:Single centre study in Odense, Denmark PARTICIPANTS:43 children previously not bicycling to school were ra...

journal_title：BMJ open

authors： Ostergaard L,Børrestad LA,Tarp J,Andersen LB

更新日期：2012-10-31 00:00:00

abstract：OBJECTIVES:Several ABILHAND Rasch-built manual ability scales were previously developed for chronic stroke (CS), cerebral palsy (CP), rheumatoid arthritis (RA), systemic sclerosis (SSc) and neuromuscular disorders (NMD). The present study aimed to explore the applicability of a generic manual ability scale unbiased by ...

journal_title：BMJ open

authors： Arnould C,Vandervelde L,Batcho CS,Penta M,Thonnard JL

更新日期：2012-10-31 00:00:00

abstract：OBJECTIVES:To evaluate a protocol for a population-based programme targeting the prevention of rheumatic heart disease (RHD) progression by early echocardiographic diagnosis of valvular lesions and timely implementation of secondary prevention. DESIGN:Observational survey with a subsequent prospective cohort study. S...

journal_title：BMJ open

authors： Shrestha NR,Kalesan B,Karki P,Sherpa K,Basnet A,Urban P,Pilgrim T

更新日期：2012-10-19 00:00:00

abstract：OBJECTIVES:To determine the effectiveness of early assisted discharge for chronic obstructive pulmonary disease (COPD) exacerbations, with home care provided by generic community nurses, compared with usual hospital care. DESIGN:Prospective, randomised controlled and multicentre trial with 3-month follow-up. SETTING:...

journal_title：BMJ open

authors： Utens CM,Goossens LM,Smeenk FW,Rutten-van Mölken MP,van Vliet M,Braken MW,van Eijsden LM,van Schayck OC

更新日期：2012-10-16 00:00:00

abstract：OBJECTIVE:To explore the views of sick doctors on the obstacles preventing them returning to work. DESIGN:Qualitative study. SETTING:Single participating centre recruiting doctors from all over the UK. PARTICIPANTS:Doctors who had been away from work for at least 6 months with physical or mental health problems, dru...

journal_title：BMJ open

authors： Henderson M,Brooks SK,Del Busso L,Chalder T,Harvey SB,Hotopf M,Madan I,Hatch S

更新日期：2012-10-15 00:00:00

abstract：OBJECTIVE:To report on the relative cost-effectiveness of total hip arthroplasty and resurfacing arthroplasty (replacement of articular surface of femoral head only) in patients with severe arthritis suitable for hip joint resurfacing arthroplasty. DESIGN:Cost-effectiveness analysis on an intention-to-treat basis of a...

journal_title：BMJ open

authors： Edlin R,Tubeuf S,Achten J,Parsons N,Costa M

更新日期：2012-10-12 00:00:00

abstract：OBJECTIVES AND DESIGN:We identified a novel TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We explore its clinical applications as a multitumour marker detecting early tumorigenesis by immunohistochemistry (IHC). SETTING AND PARTICIPANTS:88...

journal_title：BMJ open

authors： Khatamianfar V,Valiyeva F,Rennie PS,Lu WY,Yang BB,Bauman GS,Moussa M,Xuan JW

更新日期：2012-10-08 00:00:00

abstract：OBJECTIVES:To update the estimation of the adult HIV prevalence and number of people living with HIV (PLHIV) in India for the year 2008-2009 with the combination of improved data and methods. DESIGN:Based on HIV sentinel surveillance (HSS) data and a set of epidemiological assumptions, estimates of HIV prevalence and ...

journal_title：BMJ open

authors： Pandey A,Sahu D,Bakkali T,Reddy D,Venkatesh S,Kant S,Bhattacharya M,Raj Y,Haldar P,Bhardwaj D,Chandra N

更新日期：2012-09-30 00:00:00